Nutrigenomics 101: Folate and Your Genes

by Alejandra "Alex" Ruani — Get free science updates here.

Conveniently download this 50-page Science Report. Contains links to extra reading materials and scientific references.

You might already be aware that folate plays a vital role in metabolism.

But what exactly is this role?

Is there a difference between folic acid and folate?

How much do we need?

And what if you’re not like most people? Could it be because of a “faulty” gene?

If so, what should you do?

Read on to find the answers to these questions – and more!

Grab “Nutrigenomics 101: Folate and Your Genes” below:


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Conveniently download this 50-page Science Report. Contains links to extra reading materials and scientific references.

Topics covered in this report:

  1. Diving into the latest folate science
  2. Are folate and folic acid the same?
  3. What does folate do?
  4. Folate bioavailability
  5. Figure 1: Folate Metabolism
  6. Recommendations for folate (US)
  7. Recommended Dietary Allowance
  8. Recommendations for folate (UK)
  9. What if I’m not “most people”?
  10. Could a deficiency be genetic?
  11. Mutations in the MTHFR gene
  12. MTHFR enzyme deficiency
  13. Missing out on folate’s benefits
  14. Elevated homocysteine levels
  15. DNA hypo-methylation
  16. Folate or B12 deficiency?
  17. Low B12 masked by more folate
  18. B12 and the methylation cycle
  19. How prevalent are MTHFR mutations?
  20. Graph: MTHFR mutations by country
  21. Maternal and paternal 677CàT
  22. Is my MTHFR gene faulty?
  23. MTHFR genetic testing
  24. How to interpret your test results
  25. What if I have an MTHFR mutation?
  26. Increasing your folate status
  27. Table: Folate and B12 Sources
  28. Do folic acid supplements cause cancer?
  29. What kind of supplementation is best?
  30. Folic acid vs. 5-methyl THF
  31. 5-methyl THF supplements
  32. Your key takeaways
  33. Learn More
  34. References and resources


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Alex Ruani leads the research division at The Health Sciences Academy, where she and her team make sense of complex scientific literature and translate it into easy-to-understand practical concepts for students. She is a Harvard-trained scientific researcher who specialises in cravings and appetite neurobiology, nutrition biochemistry, and nutrigenomics. Besides investigating and teaching the latest advances in health and nutrition science, Alex makes it easier to be smarter with her free Science Catch-ups every other Thursday.
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