Full Yet Hungry. Appetite Neurochemistry – Part 2

by Alejandra "Alex" Ruani — Get free science updates here.

Conveniently download this 41-page Science Report. Contains links to extra reading materials and scientific references.

Have you ever wondered why we keep feeling hungry despite being full?

And how is it possible to have a starving brain… in an overweight body?

What weird biochemistry could be causing us to overeat?

If your satiety signal is broken, can it be restored?

In this Part 2, we dive deeper into the mysteries of our appetite neurochemistry to find the answers!

Grab “Full Yet Hungry. Appetite Neurochemistry – Part 2“  below:


Download PDF NOW!


Conveniently download this 41-page Science Report. Contains links to extra reading materials and scientific references.

Topics covered in this report:

  1. Unanswered questions
  2. Satiety and brain reward
  3. Food deprivation and body fat
  4. Our obesogenic environment
  5. Your hypothalamus and appetite
  6. Leptin signalling
  7. Your ARC and appetite regulation
  8. Other signals to the brain
  9. Anorexigenic vs orexigenic
  10. Figure 1: Brain Regulation of Energy Intake and Usage
  11. Things don’t add up
  12. Wishnofsky’s rule
  13. The two phases of weight loss
  14. When your ARC detects less leptin
  15. Figure 2: Compensatory Eating
  16. The “set point” theory
  17. Your body weight “thermostat”
  18. Can I change my set point?
  19. The leptin gene
  20. An anti-obesity treatment?
  21. Leptin resistance and overeating
  22. Full stomach, starved brain…
  23. A brain that doesn’t see leptin
  24. Can I restore my leptin sensitivity?
  25. Your key takeaways
  26. Learn more
  27. References and resources


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Alex Ruani leads the research division at The Health Sciences Academy, where she and her team make sense of complex scientific literature and translate it into easy-to-understand practical concepts for students. She is a Harvard-trained scientific researcher who specialises in cravings and appetite neurobiology, nutrition biochemistry, and nutrigenomics. Besides investigating and teaching the latest advances in health and nutrition science, Alex makes it easier to be smarter with her free Science Catch-ups every other Thursday.
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