Published scientific studies.

Research work published in peer-reviewed journals by the scientists in our team.

“If you want to learn science, it doesn't get any better than learning from the scientists themselves.”

Alex Ruani, Research Director

Dr Goulven Josse, PhD

Research Scientist and Lead Instructor

Automated identification of brain tumors from single MR images based on segmentation with refined patient-specific priors.

Josse G, Sanjuán A, Price CJ, Mancini L, Grogan A, Yamamoto AK, Geva S, Leff AP, Yousry TA, Seghier ML.

Front Neurosci. 2013 Dec 17;7:241. doi: 10.3389/fnins.2013.00241. eCollection 2013.

PMID: 24381535 Free PMC Article

Related citations


Rostral and caudal prefrontal contribution to creativity: a meta-analysis of functional imaging data.

Josse G, Gonen-Yaacovi G, de Souza LC, Levy R, Urbanski M, Volle E.

Front Hum Neurosci. 2013 Aug 14;7:465. doi: 10.3389/fnhum.2013.00465. eCollection 2013.

PMID: 23966927 Free PMC Article

Related citations


The influence of reading ability on subsequent changes in verbal IQ in the teenage years.

Josse G, Ramsden S, Richardson FM, Shakeshaft C, Seghier ML, Price CJ.

Dev Cogn Neurosci. 2013 Oct;6:30-9. doi: 10.1016/j.dcn.2013.06.001. Epub 2013 Jun 25.

PMID: 23872197 Free PMC Article

Related citations


The brain's dorsal route for speech represents word meaning: evidence from gesture.

Josse G, Joseph S, Bertasi E, Giraud AL.

PLoS One. 2012;7(9):e46108. doi: 10.1371/journal.pone.0046108. Epub 2012 Sep 26.

PMID: 23049951 Free PMC Article

Related citations


Verbal and non-verbal intelligence changes in the teenage brain.

Josse G, Ramsden S, Richardson FM, Thomas MS, Ellis C, Shakeshaft C, Seghier ML, Price CJ.

Nature. 2012 May 16;485(7400):666. doi: 10.1038/nature11113. No abstract available.

PMID: 22660332 Related citations


Brain-speech alignment enhances auditory cortical responses and speech perception.

Josse G, Saoud H, Bertasi E, Truy E, Chait M, Giraud AL.

J Neurosci. 2012 Jan 4;32(1):275-81. doi: 10.1523/JNEUROSCI.3970-11.2012.

PMID: 22219289 Free Article

Related citations


Verbal and non-verbal intelligence changes in the teenage brain.

Josse G, Ramsden S, Richardson FM, Thomas MS, Ellis C, Shakeshaft C, Seghier ML, Price CJ.

Nature. 2011 Oct 19;479(7371):113-6. doi: 10.1038/nature10514. Erratum in: Nature. 2012 May 31;485(7400):666.

PMID: 22012265 Free PMC Article

Related citations


Lateralization is predicted by reduced coupling from the left to right prefrontal cortex during semantic decisions on written words.

Josse G, Seghier ML, Leff AP, Price CJ.

Cereb Cortex. 2011 Jul;21(7):1519-31. doi: 10.1093/cercor/bhq203. Epub 2010 Nov 25.

PMID: 21109578 Free PMC Article

Related citations


Regional and hemispheric determinants of language laterality: implications for preoperative fMRI.

Josse G, Seghier ML, Kherif F, Price CJ.

Hum Brain Mapp. 2011 Oct;32(10):1602-14. doi: 10.1002/hbm.21130. Epub 2010 Sep 2.

PMID: 20814960 Free PMC Article

Related citations


Left hemisphere regions are critical for language in the face of early left focal brain injury.

Josse G, Raja Beharelle A, Dick AS, Solodkin A, Huttenlocher PR, Levine SC, Small SL.

Brain. 2010 Jun;133(Pt 6):1707-16. doi: 10.1093/brain/awq104. Epub 2010 May 13.

PMID: 20466762 Free PMC Article

Related citations


Automatic top-down processing explains common left occipito-temporal responses to visual words and objects.

Josse G, Kherif F, Price CJ.

Cereb Cortex. 2011 Jan;21(1):103-14. doi: 10.1093/cercor/bhq063. Epub 2010 Apr 22.

PMID: 20413450 Free PMC Article

Related citations


Predicting language lateralization from gray matter.

Josse G, Kherif F, Flandin G, Seghier ML, Price CJ.

J Neurosci. 2009 Oct 28;29(43):13516-23. doi: 10.1523/JNEUROSCI.1680-09.2009.

PMID: 19864564 Free PMC Article

Related citations


Explaining function with anatomy: language lateralization and corpus callosum size.

Josse G, Seghier ML, Kherif F, Price CJ.

J Neurosci. 2008 Dec 24;28(52):14132-9. doi: 10.1523/JNEUROSCI.4383-08.2008.

PMID: 19109495 Free PMC Article

Related citations


The main sources of intersubject variability in neuronal activation for reading aloud.

Josse G, Kherif F, Seghier ML, Price CJ.

J Cogn Neurosci. 2009 Apr;21(4):654-68. doi: 10.1162/jocn.2009.21084.

PMID: 18702580 Free PMC Article

Related citations


Hemispheric specialization for language: Brain volume matters.

Josse G, Hervé PY, Crivello F, Mazoyer B, Tzourio-Mazoyer N.

Brain Res. 2006 Jan 12;1068(1):184-93. Epub 2005 Dec 27.

PMID: 16380101

Related citations


Hemispheric specialization for language.

Josse G, Tzourio-Mazoyer N.

Brain Res Brain Res Rev. 2004 Jan;44(1):1-12. Review.

PMID: 14739000

Related citations


Inter-individual variability in the hemispheric organization for speech.

Tzourio-Mazoyer N, Josse G, Crivello F, Mazoyer B.

Neuroimage 2004. 21(1):422-35.

PMID: 14741679


Left planum temporale: an anatomical marker of left hemispheric specialization for language comprehension.

Josse G, Mazoyer B, Crivello F, Tzourio-Mazoyer N.

Brain Res Cogn Brain Res. 2003 Dec;18(1):1-14.

PMID: 14659492

Related citations


What can functional imaging of the human brain tell about handedness and language?

Josse G and Tzourio-Mazoyer N

A commentary on Michael C. Corballis' article: "From mouth to hand: Gesture, speech, and the evolution of right-handedness"

Behavioral and Brain Sciences. 2003.

Volume 26 / Issue 02 / April 2003, pp 228- 229


Peer Reviews:

Neuroimage (9 submissions), Brain and Language (3), Rubriq (2), Journal of Cognitive Neuroscience (1), Human Brain Mapping (1), Brain Research (1), Developmental Cognitive Neuroscience (1), Plos One (1), Bilingualism: Language and Cognition (1), Cognitive Science Society (1)


Book Chapters:

Josse G et Tzourio-Mazoyer N: The hemispheric specialization in Neural Basis of Language. La spécialisation hémisphérique in Bases Neurales du Langage (Tzourio-Mazoyer N, Etard O, Traité de Sciences Cognitives, Hermès Science, 2003).

Josse G and Tzourio-Mazoyer N: Hemispheric specialization for language in Brain and Psychology. La spécialisation hémisphérique pour le langage in Cerveau et Psychologie (Houdé O, Mazoyer B, Tzourio-Mazoyer N, PUF, 2002).


Journalistic Contributions: 

Josse G: Integrity and Science. "Intégrité et Science" - Chronique Web "Le Monde" 2010

Dr Josephine "JoJo" Head, PhD

Research Scientist and Lead Instructor

How environmentally sustainable are the UK’s new dietary guidelines?

Head, J. and Atherton, E.

The British Medical Journal - BMJ, March 2016


Protected areas in tropical Africa: assessing threats and conservation activities.

Tranquilli, S., Abedi-Lartey, M., Abernethy, K., Head, J. et al.

PLoS One. 2014 Dec 3;9(12):e114154. doi: 10.1371/journal.pone.0114154. eCollection 2014.

PMID: 25469888


Niche differentiation and dietary seasonality among sympatric gorillas and chimpanzees in Loango National Park (Gabon) revealed by stable isotope analysis.

Oelze VM, Head JS, Robbins MM, Richards M, Boesch C.

J Hum Evol. 2014 Jan;66:95-106. doi: 10.1016/j.jhevol.2013.10.003. Epub 2013 Dec 24.

PMID: 24373257


Genetic inference of group dynamics and female kin structure in a western lowland gorilla population (Gorilla gorilla gorilla).

Arandjelovic, M., Head, J., Boesch, C., Robbins, M.M. & Vigilant, L. (2014).

Primate Biology, 1:29-38.


Effective sociodemographic population assessment of elusive species in ecology and conservation management.

Head JS, Boesch C, Robbins MM, Rabanal LI, Makaga L, Kühl HS.

Ecol Evol. 2013 Sep;3(9):2903-16. doi: 10.1002/ece3.670. Epub 2013 Jul 30.

PMID: 24101982


Notes on the distribution and status of small carnivores in Gabon.

Bahaa-El-Din, L., Henschel, P., Abaa, K., Abernethy, K., Bohm, T., Bout, N., Coad, L., Head, J. et al. (2013).

Small Carnivore Conservation, 48:19-29


Remote video-camera traps measure habitat use and competitive exclusion among sympatric chimpanzee, gorilla and elephant in Loango National Park, Gabon.

Head, J., Robbins, M.M., Mundry, R., Makaga, L. & Boesch. C. (2012).

Journal of Tropical Ecology, 28:571-583


Recent decline in suitable environmental conditions for African great apes.

Junker, J., Kuehl, H., Head, J. et al. (2012).

Diversity and Distributions, 18:1077-1091


Sympatric chimpanzees and gorillas in Loango National Park, Gabon: Dietary composition, seasonal changes and inter-site comparisons.

Head, J., Boesch, C., Makaga, L. & Robbins, M.M. (2011).

International Journal of Primatology, 32:755-775


Feeding ecology of sympatric apes: dietary overlap and competition.

Head, J., Boesch, C., Makaga, L. & Robbins, M.M. (2011).

Gorilla Journal, 43:18-19


Non-invasive genetic monitoring of wild central chimpanzees.

Arandjelovic M, Head J, Rabanal LI, Schubert G, Mettke E, Boesch C, Robbins MM, Vigilant L.

PLoS One. 2011 Mar 15;6(3):e14761. doi: 10.1371/journal.pone.0014761.

Biological Conservation, 143:1780-1791

PMID: 21423611


Novel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissions.

Wevers, D., Metzger, S., Head, J., et al.

J Virol. 2011 Oct;85(20):10774-84. doi: 10.1128/JVI.00810-11. Epub 2011 Aug 10.

PMID: 21835802


A novel adenovirus of Western lowland gorillas (Gorilla gorilla gorilla).

Wevers D, Leendertz FH, Scuda N, Boesch C, Robbins MM, Head J, Ludwig C, Kühn J, Ehlers B.

Virol J. 2010 Nov 5;7:303. doi: 10.1186/1743-422X-7-303.

PMID: 21054831


Complex tool sets for honey extraction among chimpanzees in Loango National Park, Gabon.

Boesch C, Head J, Robbins MM.

J Hum Evol. 2009 Jun;56(6):560-9. doi: 10.1016/j.jhevol.2009.04.001. Epub 2009 May 19.

PMID: 19457542


Effective non-invasive genetic monitoring of multiple wild western gorilla groups.

Arandjelovic, M., Head, J., Boesch, C., Kuehl, H., Robbins, M.M., Maisels, F., & Vigilant, L. (2010).

Biological Conservation, 143:1780-1791


Fatal chimpanzee attack in Loango National Park, Gabon.

Boesch, C., Head, J., Tagg, N., Arandjelovic, M., Vigilant, L. & Robbins, M.M. (2007).

International Journal of Primatology, 28:1025-1034


Other Publications in Prestigious Journals:


Primate Abundance and Distribution.

Head, J., Junker, J. & Campbell, G. (in review).

In: An Introduction to Primate Conservation.

Wich, S. & Marshall, A.J. (eds).          

Oxford University Press.


Primates in African mangroves.

Head, J., Healy, A. & Nowak, K. (in press).

In: Primates in flooded habitats: ecology and conservation.

Barnett, A.A., Matsuda, I. & Nowak, K. (eds).

Cambridge University Press.


The bigger picture: indirect impacts of extractive industries on apes and habitat.

White, A., Fa, J., Arnhem, E., Colchester, M., Cugniere, L., Fankem, O., Hatchewell, M., Head, J., Kendrick, J., Meijaard, E., Morgan, D., de Ornellas, P., Bardolf, P., Ransom, C., Sanz, C., Tolisano, J., Victurine, R., Vosper, A. & Wich, A. (2014).

In: State of the Apes, Extractive Industries and Ape Conservation. pp. 197-225.

Rainer, A. White & A. Lanjouw (eds.)

Cambridge University Press, UK.


Keeping it in the Family: Tribal Warfare between Chimpanzee Communities.

Head, J. (2011).

In: Among African Apes: Stories and photos from the field.

Robbins, MM and Boesch, C. (eds).

Berkeley: University of California Press.

Dr Michelle de la Vega, PhD

Research Scientist and Lead Instructor

Bit-1 is an essential regulator of myogenic differentiation.

Griffiths GS, Doe J, Jijiwa M, Van Ry P, Cruz V, de la Vega M, Ramos JW, Burkin DJ, Matter ML.

J Cell Sci. 2015 Mar 13. pii: jcs.158964. [Epub ahead of print]

PMID: 25770104


Mutations in PTRH2 cause novel infantile-onset multisystem disease with intellectual disability, microcephaly, progressive ataxia, and muscle weakness.

Hu H, Matter ML, Issa-Jahns L, Jijiwa M, Kraemer N, Musante L, de la Vega M, et al.

Ann Clin Transl Neurol. 2014 Dec;1(12):1024-35. doi: 10.1002/acn3.149. Epub 2014 Dec 3.

PMID: 25574476 Free PMC Article

Related citations


USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor.

Jaworski J, de la Vega M, Fletcher SJ, McFarlane C, Greene MK, Smyth AW, Van Schaeybroeck S, Johnston JA, Scott CJ, Rappoport JZ, Burrows JF.

Oncotarget. 2014 Aug 30;5(16):6964-75.

PMID: 25026282 Free PMC Article

Related citations


A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17.

Jaworski J, Govender U, McFarlane C, de la Vega M, Greene MK, Rawlings ND, Johnston JA, Scott CJ, Burrows JF.

Biochem J. 2014 Jan 15;457(2):289-300. doi: 10.1042/BJ20131213.

PMID: 24134311 Free Article

Related citations


Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion.

de la Vega M, Marin M, Kondo N, Miyauchi K, Kim Y, Epand RF, Epand RM, Melikyan GB.

Retrovirology. 2011 Dec 6;8:99. doi: 10.1186/1742-4690-8-99.

PMID: 22145853 Free PMC Article

Related citations


Ubiquitination: Added complexity in Ras and Rho family GTPase function.

de la Vega M, Burrows JF, Johnston JA.

Small GTPases. 2011 Jul;2(4):192-201. Epub 2011 Jul 1.

PMID: 22145091 Free PMC Article

Related citations


The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.

de la Vega M, Kelvin AA, Dunican DJ, McFarlane C, Burrows JF, Jaworski J, Stevenson NJ, Dib K, Rappoport JZ, Scott CJ, Long A, Johnston JA.

Nat Commun. 2011 Mar 29;2:259. doi: 10.1038/ncomms1243.

PMID: 21448158 Free PMC Article

Related citations


The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.

McFarlane C, Kelvin AA, de la Vega M, Govender U, Scott CJ, Burrows JF, Johnston JA.

Cancer Res. 2010 Apr 15;70(8):3329-39. doi: 10.1158/0008-5472.CAN-09-4152. Epub 2010 Apr 13.

PMID: 20388806 Free Article

Related citations


The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

de la Vega M, Burrows JF, McFarlane C, Govender U, Scott CJ, Johnston JA.

J Biol Chem. 2010 Apr 16;285(16):12028-36. doi: 10.1074/jbc.M109.081448. Epub 2010 Feb 10.

PMID: 20147298 Free PMC Article

Related citations


USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.

Burrows JF, Kelvin AA, McFarlane C, Burden RE, McGrattan MJ, De la Vega M, Govender U, Quinn DJ, Dib K, Gadina M, Scott CJ, Johnston JA.

J Biol Chem. 2009 Apr 3;284(14):9587-95. doi: 10.1074/jbc.M807216200. Epub 2009 Feb 2.

PMID: 19188362 Free PMC Article

Related citations


Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.

Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau LA, Shimamura A, D'Andrea AD.

J Clin Invest. 2007 May;117(5):1440-9. Epub 2007 Apr 12.

PMID: 17431503 Free PMC Article

Related citations


Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway.

Chirnomas D, Taniguchi T, de la Vega M, Vaidya AP, Vasserman M, Hartman AR, Kennedy R, Foster R, Mahoney J, Seiden MV, D'Andrea AD.

Mol Cancer Ther. 2006 Apr;5(4):952-61.

PMID: 16648566 Free Article

Related citations

Dr Chinmay R Munje, PhD

Research Scientist and Contributor

Cord Blood-Derived Quiescent CD34+ Cells Are More Transcriptionally Matched to AML Blasts Than Cytokine-Induced Normal Human Hematopoietic CD34+ Cells

Munje C, Hills RK, Whetton A, Burnett AK, Darley RL, Tonks A.

Gene Expression. 2015;16(4):169-75. doi: 10.3727/105221615X14399878166159.

PMID: 26637397

Related citations


Could upregulated Hsp70 protein compensate for the Hsp90 silence induced cell death in glioma cells?

Munje, C., Shervington, L., Khan, Z., Shervington, A.

International Journal of Brain Science. 2014.

Article ID 652643.


Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling.

Hole PS, Zabkiewicz J, Munje C, Newton Z, Pearn L, White P, Marquez N, Hills RK, Burnett AK, Tonks A, Darley RL.

Blood. 2013 Nov 7;122(19):3322-30. doi: 10.1182/blood-2013-04-491944. Epub 2013 Oct 2.

PMID: 24089327 Free Article

Related citations


The complexity of identifying cancer stem cell biomarkers.

Khan Z, Shervington A, Munje C, Shervington L.

Cancer Invest. 2013 Jul;31(6):404-11. doi: 10.3109/07357907.2013.802800. Epub 2013 Jun 11.

PMID: 23758188

Related citations


A novel therapeutic strategy for the treatment of glioma, combining chemical and molecular targeting of hsp90a.

Mehta A, Shervington L, Munje C, Shervington A.

Cancers (Basel). 2011 Dec 8;3(4):4228-44. doi: 10.3390/cancers3044228.

PMID: 24213135 Free PMC Article

Related citations


Can hsp90alpha-targeted siRNA combined with TMZ be a future therapy for glioma?

Cruickshanks N, Shervington L, Patel R, Munje C, Thakkar D, Shervington A.

Cancer Invest. 2010 Jul;28(6):608-14. doi: 10.3109/07357901003630967.

PMID: 20210521

Related citations


Validating the efficacy of shRNA vs. siRNA in silencing hsp90α in gliomas.

Munje, C., Shervington, L., Mehta, A., Khan, Z., Shervington, A.

Journal of Bioanalysis and Biomedicine. 2011; 3(6)

S3:002. doi:10.4172/1948-593X.S3-002

Dr Laurent Dumartin, PhD

Research Scientist and Contributor

Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma.

Radon TP, Massat NJ, Jones R, Alrawashdeh W, Dumartin L, Ennis D, Duffy SW, Kocher HM, Pereira SP, Guarner posthumous L, Murta-Nascimento C, Real FX, Malats N, Neoptolemos J, Costello E, Greenhalf W, Lemoine NR, Crnogorac-Jurcevic T.

Clin Cancer Res. 2015 Aug 1;21(15):3512-21. doi: 10.1158/1078-0432.CCR-14-2467.

PMID: 26240291 Free PMC Article

Related citations


A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma.

Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T, Marshall JF, Kocher HM, Crnogorac-Jurcevic T, Scarpa A, Lemoine NR, Chelala C.

Genome Med. 2014 Dec 3;6(12):105. doi: 10.1186/s13073-014-0105-3. eCollection 2014.

PMID: 25587357 Free PMC Article

Related citations


AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.

Dumartin L, Whiteman HJ, Weeks ME, Hariharan D, Dmitrovic B, Iacobuzio-Donahue CA, Brentnall TA, Bronner MP, Feakins RM, Timms JF, Brennan C, Lemoine NR, Crnogorac-Jurcevic T.

Cancer Res. 2011 Nov 15;71(22):7091-102. doi: 10.1158/0008-5472.CAN-11-1367. Epub 2011 Sep 26.

PMID: 21948970 Free PMC Article

Related citations


Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells.

Dumartin L, Quemener C, Laklai H, Herbert J, Bicknell R, Bousquet C, Pyronnet S, Castronovo V, Schilling MK, Bikfalvi A, Hagedorn M.

Gastroenterology. 2010 Apr;138(4):1595-606, 1606.e1-8. doi: 10.1053/j.gastro.2009.12.061. Epub 2010 Jan 18.

PMID: 20080097

Related citations


Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer.

Laklai H, Laval S, Dumartin L, Rochaix P, Hagedorn M, Bikfalvi A, Le Guellec S, Delisle MB, Schally AV, Susini C, Pyronnet S, Bousquet C.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17769-74. doi: 10.1073/pnas.0908674106. Epub 2009 Oct 1.

PMID: 19805200 Free PMC Article

Related citations

Cassandra Ellis, MSc ANutr

Research Scientist and Science Writer

Are meal deals making us fat? An investigation into whether cost-led meal deals encourage increased energy, saturated fat, sugar and salt consumption.

C.H. Ellis and D. Bhakta

2016. Proceedings of the Nutrition Society, 75, E10 doi:10.1017/S0029665115004437

Cambridge University Press