Published scientific studies.

Research work published in peer-reviewed journals by the scientists in our team.

“If you want to learn science, it doesn't get any better than learning from the scientists themselves.”

Alex Ruani, Research Director

Dr Goulven Josse, PhD

Research Scientist and Lead Instructor

Automated identification of brain tumors from single MR images based on segmentation with refined patient-specific priors.

Josse G, Sanjuán A, Price CJ, Mancini L, Grogan A, Yamamoto AK, Geva S, Leff AP, Yousry TA, Seghier ML.

Front Neurosci. 2013 Dec 17;7:241. doi: 10.3389/fnins.2013.00241. eCollection 2013.

PMID: 24381535 Free PMC Article

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Rostral and caudal prefrontal contribution to creativity: a meta-analysis of functional imaging data.

Josse G, Gonen-Yaacovi G, de Souza LC, Levy R, Urbanski M, Volle E.

Front Hum Neurosci. 2013 Aug 14;7:465. doi: 10.3389/fnhum.2013.00465. eCollection 2013.

PMID: 23966927 Free PMC Article

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The influence of reading ability on subsequent changes in verbal IQ in the teenage years.

Josse G, Ramsden S, Richardson FM, Shakeshaft C, Seghier ML, Price CJ.

Dev Cogn Neurosci. 2013 Oct;6:30-9. doi: 10.1016/j.dcn.2013.06.001. Epub 2013 Jun 25.

PMID: 23872197 Free PMC Article

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The brain's dorsal route for speech represents word meaning: evidence from gesture.

Josse G, Joseph S, Bertasi E, Giraud AL.

PLoS One. 2012;7(9):e46108. doi: 10.1371/journal.pone.0046108. Epub 2012 Sep 26.

PMID: 23049951 Free PMC Article

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Verbal and non-verbal intelligence changes in the teenage brain.

Josse G, Ramsden S, Richardson FM, Thomas MS, Ellis C, Shakeshaft C, Seghier ML, Price CJ.

Nature. 2012 May 16;485(7400):666. doi: 10.1038/nature11113. No abstract available.

PMID: 22660332 Related citations


Brain-speech alignment enhances auditory cortical responses and speech perception.

Josse G, Saoud H, Bertasi E, Truy E, Chait M, Giraud AL.

J Neurosci. 2012 Jan 4;32(1):275-81. doi: 10.1523/JNEUROSCI.3970-11.2012.

PMID: 22219289 Free Article

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Verbal and non-verbal intelligence changes in the teenage brain.

Josse G, Ramsden S, Richardson FM, Thomas MS, Ellis C, Shakeshaft C, Seghier ML, Price CJ.

Nature. 2011 Oct 19;479(7371):113-6. doi: 10.1038/nature10514. Erratum in: Nature. 2012 May 31;485(7400):666.

PMID: 22012265 Free PMC Article

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Lateralization is predicted by reduced coupling from the left to right prefrontal cortex during semantic decisions on written words.

Josse G, Seghier ML, Leff AP, Price CJ.

Cereb Cortex. 2011 Jul;21(7):1519-31. doi: 10.1093/cercor/bhq203. Epub 2010 Nov 25.

PMID: 21109578 Free PMC Article

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Regional and hemispheric determinants of language laterality: implications for preoperative fMRI.

Josse G, Seghier ML, Kherif F, Price CJ.

Hum Brain Mapp. 2011 Oct;32(10):1602-14. doi: 10.1002/hbm.21130. Epub 2010 Sep 2.

PMID: 20814960 Free PMC Article

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Left hemisphere regions are critical for language in the face of early left focal brain injury.

Josse G, Raja Beharelle A, Dick AS, Solodkin A, Huttenlocher PR, Levine SC, Small SL.

Brain. 2010 Jun;133(Pt 6):1707-16. doi: 10.1093/brain/awq104. Epub 2010 May 13.

PMID: 20466762 Free PMC Article

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Automatic top-down processing explains common left occipito-temporal responses to visual words and objects.

Josse G, Kherif F, Price CJ.

Cereb Cortex. 2011 Jan;21(1):103-14. doi: 10.1093/cercor/bhq063. Epub 2010 Apr 22.

PMID: 20413450 Free PMC Article

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Predicting language lateralization from gray matter.

Josse G, Kherif F, Flandin G, Seghier ML, Price CJ.

J Neurosci. 2009 Oct 28;29(43):13516-23. doi: 10.1523/JNEUROSCI.1680-09.2009.

PMID: 19864564 Free PMC Article

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Explaining function with anatomy: language lateralization and corpus callosum size.

Josse G, Seghier ML, Kherif F, Price CJ.

J Neurosci. 2008 Dec 24;28(52):14132-9. doi: 10.1523/JNEUROSCI.4383-08.2008.

PMID: 19109495 Free PMC Article

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The main sources of intersubject variability in neuronal activation for reading aloud.

Josse G, Kherif F, Seghier ML, Price CJ.

J Cogn Neurosci. 2009 Apr;21(4):654-68. doi: 10.1162/jocn.2009.21084.

PMID: 18702580 Free PMC Article

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Hemispheric specialization for language: Brain volume matters.

Josse G, Hervé PY, Crivello F, Mazoyer B, Tzourio-Mazoyer N.

Brain Res. 2006 Jan 12;1068(1):184-93. Epub 2005 Dec 27.

PMID: 16380101

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Hemispheric specialization for language.

Josse G, Tzourio-Mazoyer N.

Brain Res Brain Res Rev. 2004 Jan;44(1):1-12. Review.

PMID: 14739000

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Inter-individual variability in the hemispheric organization for speech.

Tzourio-Mazoyer N, Josse G, Crivello F, Mazoyer B.

Neuroimage 2004. 21(1):422-35.

PMID: 14741679


Left planum temporale: an anatomical marker of left hemispheric specialization for language comprehension.

Josse G, Mazoyer B, Crivello F, Tzourio-Mazoyer N.

Brain Res Cogn Brain Res. 2003 Dec;18(1):1-14.

PMID: 14659492

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What can functional imaging of the human brain tell about handedness and language?

Josse G and Tzourio-Mazoyer N

A commentary on Michael C. Corballis' article: "From mouth to hand: Gesture, speech, and the evolution of right-handedness"

Behavioral and Brain Sciences. 2003.

Volume 26 / Issue 02 / April 2003, pp 228- 229


Peer Reviews:

Neuroimage (9 submissions), Brain and Language (3), Rubriq (2), Journal of Cognitive Neuroscience (1), Human Brain Mapping (1), Brain Research (1), Developmental Cognitive Neuroscience (1), Plos One (1), Bilingualism: Language and Cognition (1), Cognitive Science Society (1)


Book Chapters:

Josse G et Tzourio-Mazoyer N: The hemispheric specialization in Neural Basis of Language. La spécialisation hémisphérique in Bases Neurales du Langage (Tzourio-Mazoyer N, Etard O, Traité de Sciences Cognitives, Hermès Science, 2003).

Josse G and Tzourio-Mazoyer N: Hemispheric specialization for language in Brain and Psychology. La spécialisation hémisphérique pour le langage in Cerveau et Psychologie (Houdé O, Mazoyer B, Tzourio-Mazoyer N, PUF, 2002).


Journalistic Contributions: 

Josse G: Integrity and Science. "Intégrité et Science" - Chronique Web "Le Monde" 2010

Dr Josephine "JoJo" Head, PhD

Research Scientist and Lead Instructor

How environmentally sustainable are the UK’s new dietary guidelines?

Head, J. and Atherton, E.

The British Medical Journal - BMJ, March 2016


Protected areas in tropical Africa: assessing threats and conservation activities.

Tranquilli, S., Abedi-Lartey, M., Abernethy, K., Head, J. et al.

PLoS One. 2014 Dec 3;9(12):e114154. doi: 10.1371/journal.pone.0114154. eCollection 2014.

PMID: 25469888


Niche differentiation and dietary seasonality among sympatric gorillas and chimpanzees in Loango National Park (Gabon) revealed by stable isotope analysis.

Oelze VM, Head JS, Robbins MM, Richards M, Boesch C.

J Hum Evol. 2014 Jan;66:95-106. doi: 10.1016/j.jhevol.2013.10.003. Epub 2013 Dec 24.

PMID: 24373257


Genetic inference of group dynamics and female kin structure in a western lowland gorilla population (Gorilla gorilla gorilla).

Arandjelovic, M., Head, J., Boesch, C., Robbins, M.M. & Vigilant, L. (2014).

Primate Biology, 1:29-38.


Effective sociodemographic population assessment of elusive species in ecology and conservation management.

Head JS, Boesch C, Robbins MM, Rabanal LI, Makaga L, Kühl HS.

Ecol Evol. 2013 Sep;3(9):2903-16. doi: 10.1002/ece3.670. Epub 2013 Jul 30.

PMID: 24101982


Notes on the distribution and status of small carnivores in Gabon.

Bahaa-El-Din, L., Henschel, P., Abaa, K., Abernethy, K., Bohm, T., Bout, N., Coad, L., Head, J. et al. (2013).

Small Carnivore Conservation, 48:19-29


Remote video-camera traps measure habitat use and competitive exclusion among sympatric chimpanzee, gorilla and elephant in Loango National Park, Gabon.

Head, J., Robbins, M.M., Mundry, R., Makaga, L. & Boesch. C. (2012).

Journal of Tropical Ecology, 28:571-583


Recent decline in suitable environmental conditions for African great apes.

Junker, J., Kuehl, H., Head, J. et al. (2012).

Diversity and Distributions, 18:1077-1091


Sympatric chimpanzees and gorillas in Loango National Park, Gabon: Dietary composition, seasonal changes and inter-site comparisons.

Head, J., Boesch, C., Makaga, L. & Robbins, M.M. (2011).

International Journal of Primatology, 32:755-775


Feeding ecology of sympatric apes: dietary overlap and competition.

Head, J., Boesch, C., Makaga, L. & Robbins, M.M. (2011).

Gorilla Journal, 43:18-19


Non-invasive genetic monitoring of wild central chimpanzees.

Arandjelovic M, Head J, Rabanal LI, Schubert G, Mettke E, Boesch C, Robbins MM, Vigilant L.

PLoS One. 2011 Mar 15;6(3):e14761. doi: 10.1371/journal.pone.0014761.

Biological Conservation, 143:1780-1791

PMID: 21423611


Novel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissions.

Wevers, D., Metzger, S., Head, J., et al.

J Virol. 2011 Oct;85(20):10774-84. doi: 10.1128/JVI.00810-11. Epub 2011 Aug 10.

PMID: 21835802


A novel adenovirus of Western lowland gorillas (Gorilla gorilla gorilla).

Wevers D, Leendertz FH, Scuda N, Boesch C, Robbins MM, Head J, Ludwig C, Kühn J, Ehlers B.

Virol J. 2010 Nov 5;7:303. doi: 10.1186/1743-422X-7-303.

PMID: 21054831


Complex tool sets for honey extraction among chimpanzees in Loango National Park, Gabon.

Boesch C, Head J, Robbins MM.

J Hum Evol. 2009 Jun;56(6):560-9. doi: 10.1016/j.jhevol.2009.04.001. Epub 2009 May 19.

PMID: 19457542


Effective non-invasive genetic monitoring of multiple wild western gorilla groups.

Arandjelovic, M., Head, J., Boesch, C., Kuehl, H., Robbins, M.M., Maisels, F., & Vigilant, L. (2010).

Biological Conservation, 143:1780-1791


Fatal chimpanzee attack in Loango National Park, Gabon.

Boesch, C., Head, J., Tagg, N., Arandjelovic, M., Vigilant, L. & Robbins, M.M. (2007).

International Journal of Primatology, 28:1025-1034


Other Publications in Prestigious Journals:


Primate Abundance and Distribution.

Head, J., Junker, J. & Campbell, G. (in review).

In: An Introduction to Primate Conservation.

Wich, S. & Marshall, A.J. (eds).          

Oxford University Press.


Primates in African mangroves.

Head, J., Healy, A. & Nowak, K. (in press).

In: Primates in flooded habitats: ecology and conservation.

Barnett, A.A., Matsuda, I. & Nowak, K. (eds).

Cambridge University Press.


The bigger picture: indirect impacts of extractive industries on apes and habitat.

White, A., Fa, J., Arnhem, E., Colchester, M., Cugniere, L., Fankem, O., Hatchewell, M., Head, J., Kendrick, J., Meijaard, E., Morgan, D., de Ornellas, P., Bardolf, P., Ransom, C., Sanz, C., Tolisano, J., Victurine, R., Vosper, A. & Wich, A. (2014).

In: State of the Apes, Extractive Industries and Ape Conservation. pp. 197-225.

Rainer, A. White & A. Lanjouw (eds.)

Cambridge University Press, UK.


Keeping it in the Family: Tribal Warfare between Chimpanzee Communities.

Head, J. (2011).

In: Among African Apes: Stories and photos from the field.

Robbins, MM and Boesch, C. (eds).

Berkeley: University of California Press.

Dr Michelle de la Vega, PhD

Research Scientist and Lead Instructor

Bit-1 is an essential regulator of myogenic differentiation.

Griffiths GS, Doe J, Jijiwa M, Van Ry P, Cruz V, de la Vega M, Ramos JW, Burkin DJ, Matter ML.

J Cell Sci. 2015 Mar 13. pii: jcs.158964. [Epub ahead of print]

PMID: 25770104


Mutations in PTRH2 cause novel infantile-onset multisystem disease with intellectual disability, microcephaly, progressive ataxia, and muscle weakness.

Hu H, Matter ML, Issa-Jahns L, Jijiwa M, Kraemer N, Musante L, de la Vega M, et al.

Ann Clin Transl Neurol. 2014 Dec;1(12):1024-35. doi: 10.1002/acn3.149. Epub 2014 Dec 3.

PMID: 25574476 Free PMC Article

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USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor.

Jaworski J, de la Vega M, Fletcher SJ, McFarlane C, Greene MK, Smyth AW, Van Schaeybroeck S, Johnston JA, Scott CJ, Rappoport JZ, Burrows JF.

Oncotarget. 2014 Aug 30;5(16):6964-75.

PMID: 25026282 Free PMC Article

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A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17.

Jaworski J, Govender U, McFarlane C, de la Vega M, Greene MK, Rawlings ND, Johnston JA, Scott CJ, Burrows JF.

Biochem J. 2014 Jan 15;457(2):289-300. doi: 10.1042/BJ20131213.

PMID: 24134311 Free Article

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Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion.

de la Vega M, Marin M, Kondo N, Miyauchi K, Kim Y, Epand RF, Epand RM, Melikyan GB.

Retrovirology. 2011 Dec 6;8:99. doi: 10.1186/1742-4690-8-99.

PMID: 22145853 Free PMC Article

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Ubiquitination: Added complexity in Ras and Rho family GTPase function.

de la Vega M, Burrows JF, Johnston JA.

Small GTPases. 2011 Jul;2(4):192-201. Epub 2011 Jul 1.

PMID: 22145091 Free PMC Article

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The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.

de la Vega M, Kelvin AA, Dunican DJ, McFarlane C, Burrows JF, Jaworski J, Stevenson NJ, Dib K, Rappoport JZ, Scott CJ, Long A, Johnston JA.

Nat Commun. 2011 Mar 29;2:259. doi: 10.1038/ncomms1243.

PMID: 21448158 Free PMC Article

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The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.

McFarlane C, Kelvin AA, de la Vega M, Govender U, Scott CJ, Burrows JF, Johnston JA.

Cancer Res. 2010 Apr 15;70(8):3329-39. doi: 10.1158/0008-5472.CAN-09-4152. Epub 2010 Apr 13.

PMID: 20388806 Free Article

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The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

de la Vega M, Burrows JF, McFarlane C, Govender U, Scott CJ, Johnston JA.

J Biol Chem. 2010 Apr 16;285(16):12028-36. doi: 10.1074/jbc.M109.081448. Epub 2010 Feb 10.

PMID: 20147298 Free PMC Article

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USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.

Burrows JF, Kelvin AA, McFarlane C, Burden RE, McGrattan MJ, De la Vega M, Govender U, Quinn DJ, Dib K, Gadina M, Scott CJ, Johnston JA.

J Biol Chem. 2009 Apr 3;284(14):9587-95. doi: 10.1074/jbc.M807216200. Epub 2009 Feb 2.

PMID: 19188362 Free PMC Article

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Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.

Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau LA, Shimamura A, D'Andrea AD.

J Clin Invest. 2007 May;117(5):1440-9. Epub 2007 Apr 12.

PMID: 17431503 Free PMC Article

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Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway.

Chirnomas D, Taniguchi T, de la Vega M, Vaidya AP, Vasserman M, Hartman AR, Kennedy R, Foster R, Mahoney J, Seiden MV, D'Andrea AD.

Mol Cancer Ther. 2006 Apr;5(4):952-61.

PMID: 16648566 Free Article

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Dr Chinmay R Munje, PhD

Research Scientist and Contributor

Cord Blood-Derived Quiescent CD34+ Cells Are More Transcriptionally Matched to AML Blasts Than Cytokine-Induced Normal Human Hematopoietic CD34+ Cells

Munje C, Hills RK, Whetton A, Burnett AK, Darley RL, Tonks A.

Gene Expression. 2015;16(4):169-75. doi: 10.3727/105221615X14399878166159.

PMID: 26637397

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Could upregulated Hsp70 protein compensate for the Hsp90 silence induced cell death in glioma cells?

Munje, C., Shervington, L., Khan, Z., Shervington, A.

International Journal of Brain Science. 2014.

Article ID 652643.


Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling.

Hole PS, Zabkiewicz J, Munje C, Newton Z, Pearn L, White P, Marquez N, Hills RK, Burnett AK, Tonks A, Darley RL.

Blood. 2013 Nov 7;122(19):3322-30. doi: 10.1182/blood-2013-04-491944. Epub 2013 Oct 2.

PMID: 24089327 Free Article

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The complexity of identifying cancer stem cell biomarkers.

Khan Z, Shervington A, Munje C, Shervington L.

Cancer Invest. 2013 Jul;31(6):404-11. doi: 10.3109/07357907.2013.802800. Epub 2013 Jun 11.

PMID: 23758188

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A novel therapeutic strategy for the treatment of glioma, combining chemical and molecular targeting of hsp90a.

Mehta A, Shervington L, Munje C, Shervington A.

Cancers (Basel). 2011 Dec 8;3(4):4228-44. doi: 10.3390/cancers3044228.

PMID: 24213135 Free PMC Article

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Can hsp90alpha-targeted siRNA combined with TMZ be a future therapy for glioma?

Cruickshanks N, Shervington L, Patel R, Munje C, Thakkar D, Shervington A.

Cancer Invest. 2010 Jul;28(6):608-14. doi: 10.3109/07357901003630967.

PMID: 20210521

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Validating the efficacy of shRNA vs. siRNA in silencing hsp90α in gliomas.

Munje, C., Shervington, L., Mehta, A., Khan, Z., Shervington, A.

Journal of Bioanalysis and Biomedicine. 2011; 3(6)

S3:002. doi:10.4172/1948-593X.S3-002

Dr Laurent Dumartin, PhD

Research Scientist and Contributor

Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer.

Quemener C, Baud J, Boyé K, Dubrac A, Billottet C, Soulet F, Darlot F, Dumartin L, Sire M, Grepin R, Daubon T, Rayne F, Wodrich H, Couvelard A, Pineau R, Schilling M, Castronovo V, Sue SC, Clarke K, Lomri A, Khatib AM, Hagedorn M, Prats H, Bikfalvi A.

Cancer Res. 2016 Nov 15;76(22):6507-6519. doi: 10.1158/0008-5472.CAN-15-2864. Epub 2016 Sep 9.


Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma.

Radon TP, Massat NJ, Jones R, Alrawashdeh W, Dumartin L, Ennis D, Duffy SW, Kocher HM, Pereira SP, Guarner posthumous L, Murta-Nascimento C, Real FX, Malats N, Neoptolemos J, Costello E, Greenhalf W, Lemoine NR, Crnogorac-Jurcevic T.

Clin Cancer Res. 2015 Aug 1;21(15):3512-21. doi: 10.1158/1078-0432.CCR-14-2467.

PMID: 26240291 Free PMC Article

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A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma.

Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T, Marshall JF, Kocher HM, Crnogorac-Jurcevic T, Scarpa A, Lemoine NR, Chelala C.

Genome Med. 2014 Dec 3;6(12):105. doi: 10.1186/s13073-014-0105-3. eCollection 2014.

PMID: 25587357 Free PMC Article

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AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.

Dumartin L, Whiteman HJ, Weeks ME, Hariharan D, Dmitrovic B, Iacobuzio-Donahue CA, Brentnall TA, Bronner MP, Feakins RM, Timms JF, Brennan C, Lemoine NR, Crnogorac-Jurcevic T.

Cancer Res. 2011 Nov 15;71(22):7091-102. doi: 10.1158/0008-5472.CAN-11-1367. Epub 2011 Sep 26.

PMID: 21948970 Free PMC Article

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Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells.

Dumartin L, Quemener C, Laklai H, Herbert J, Bicknell R, Bousquet C, Pyronnet S, Castronovo V, Schilling MK, Bikfalvi A, Hagedorn M.

Gastroenterology. 2010 Apr;138(4):1595-606, 1606.e1-8. doi: 10.1053/j.gastro.2009.12.061. Epub 2010 Jan 18.

PMID: 20080097

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Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer.

Laklai H, Laval S, Dumartin L, Rochaix P, Hagedorn M, Bikfalvi A, Le Guellec S, Delisle MB, Schally AV, Susini C, Pyronnet S, Bousquet C.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17769-74. doi: 10.1073/pnas.0908674106. Epub 2009 Oct 1.

PMID: 19805200 Free PMC Article

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Cassandra Ellis, MSc ANutr

Research Scientist and Science Writer

Are meal deals making us fat? An investigation into whether cost-led meal deals encourage increased energy, saturated fat, sugar and salt consumption.

C.H. Ellis and D. Bhakta

2016. Proceedings of the Nutrition Society, 75, E10 doi:10.1017/S0029665115004437

Cambridge University Press


Global and National Public Health Nutrition Approaches

Francesco Branca and Cassandra H Ellis

Public Health Nutrition, 2nd Edition

Judith L. Buttriss (Editor), Ailsa A. Welch (Editor), John M. Kearney (Editor), Susan A. Lanham-New (Editor)

ISBN: 978-1-118-66097-3

456 pages June 2017, Wiley-Blackwell

Dr Peter H. Kay, PhD

Research Scientist and Science Educator

Invited reviews:

Kay PH, Spagnolo DV, Taylor JME, Ziman M. DNA methylation and developmental genes in lymphomagenesis - more questions than answers? Leukemia Lymphoma 24:211-220. (1997).

Kay PH, Jacobsen PF, Taylor J, Spagnolo DV. The significance of DNA methylation in cancer. Adv Anat Path 2:353-361. (1995).

Kay PH, Papadimitriou JM. What's new in the role of complement in disease? Path Res Pract 186:410-414. (1990).

Invited chapters in book:

Taylor JME, Kay PH, Spagnolo DV. The diagnostic and prognostic significance of the methylation status of Myf-3 in lymphoproliferative disorders. In: Molecular Diagnosis of Cancer. Eds. J.Bartlett, J. Roulston. Humana Press, Totowa. (2002).

Kay PH, Dawkins RL. Complement genetics and disease. In: Complement in Health and Disease. Ed. K. Whaley. MTP Press, Lancaster. (1986).

List of refereed publications:

Pelham J. Irwin PJ, Kay PH. Genomic hypomethylation in neoplastic cells from dogs with lymphoproliferative disorders. Res Vet Sci 74: 101-4 (2003).

Franchina M, Kay PH. DNMT1 Gene copy number does not influence susceptibility to malignant lymphoproliferative disease. Anti-Cancer Res 22:3405-7 (2002).

Taylor JM, Kay PH, Spagnolo DV. The diagnostic significance of Myf-3 hypermethylation in malignant lymphoproliferative disorders. Leukemia. 15:583-589 (2001).

Franchina M, Hooper J, Kay PH. Five novel alternatively spliced transcripts of DNA(cytosine-5) methyltransferase2 in human peripheral blood leukocytes. Int J of Biochem Cell Biol 33: 1104-1115 (2001).

Franchina M, Kay PH. Novel nucleotide substitutions within the coding region of DNMT2 are in strong linkage disequilibrium in Caucasians and Japanese. Hum Hered 52: 210-216 (2001).

Franchina M, Kay PH. Evidence that cytosine residues within 5’-CCTGG-3’ pentanucleotides can be methylated in human DNA independently of the methylating system which modifies 5’-CG-3’ dinucleotides. DNA Cell Biol 19:521-526 (2000).

Butler TL, Kay PH, Jacobsen, PF. Hypomethylation of cytosine 5-methyltransferase in human neoplasms. Anti-cancer Res 20:1435-1438 (2000).

Franchina M, Kay PH. Allele-specific variation in the gene copy number of human cytosine 5-methyltransferase. Hum Hered 50:112-117 (2000).

Rodger J, Ziman MR, Papadimitriou JM, Kay PH. Pax7 is expressed in the capsules surrounding adult mouse neuromuscular spindles. Biochem Cell Biol 77:153-156 (1999).

Kay PH, Ziman MR. Alternate Pax7 paired box transcripts which include a trinucleotide or a hexanucleotide are generated by use of alternate 3’ intronic splice sites which are not utilised in the ancestral homologue. Gene 230:55-60 (1999).

Shannon B, Kay PH, House A, Iacopetta B. Hypermethylation of the Myf-3 gene in colorectal cancers: associations with pathological features and with microsatellite instability. Int J Cancer 84:109-113 (1999).

Ziman MR, Kay PH. A conserved TN8TCCT motif in the octopeptide encoding region of Pax genes which has the potential to direct cytosine methylation. Gene 223:303-308 (1998).

Ziman MR, Kay PH. Differential expression of four alternate Pax7 paired box transcripts is influenced by organ and strain specific factors in adult mice. Gene 217:77-81 (1998).

Kay PH, Hahnel R, Gunn H, Harmon, Song J. Hypermethylation of Hpall recognition sequences within the 5’ coding region of the estrogen receptor gene is not associated with estrogen receptor negativity in primary breast tumours. Anti-cancer Res. 18:1709-1712

Bagwe AN, Ahmed MO, Franchina M, Spagnolo DV, Papadimitriou JM, Kay PH. A novel Msp1 PCR-RFLP in the human cytosine 5 methyltransferase gene: lack of relevance for malignant lymphoproliferative disease and breast cancer. Hum Hered 48:226-229 (1998).

Kay PH, Harmon D, Fletcher S, Robertson T, Ziman M, Papadimitriou JM. Pax7 includes two polymorphic homeoboxes which contain rearrangements associated with differences in the ability to regenerate damaged skeletal muscle in adult mice. Int J Biochem Cell Biol 30:261-269 (1998).

Bagwe AN, Kay PH, Spagnolo DV. Evidence that DNA methylation imbalance is not involved in the development of malignant mesothelioma. Anticancer Research 17:3341-3344 (1997).

Taylor JM, Spagnolo DV, Kay PH. B-cell target DNA quantity is a critical factor in the interpretation of B-cell clonality by PCR. Pathology 29:309-312 (1997).

Ziman MR, Fletcher S, Kay PH. Alternate Pax7 transcripts are expressed specifically in skeletal muscle, brain and other organs of adult mice. Int J Biochem Cell Biol 29:1029-1036 (1997).

Kay PH, Harmon D, Fletcher S, Ziman M, Jacobsen PF, Papadimitriou JM. Variation in the methylation profile and structure of Pax3 and Pax7 among different mouse strains and during expression. Gene 184:45-53 (1997).

Kay PH, Spagnolo DV, Taylor J, Ziman M. DNA methylation and developmental genes in lymphomagenesis - more questions than answers? Leukemia Lymphoma 24:211-220(1997).

Marlow SA, Kay PH, McGeachie JK, Papadimitriou JM. Investigation of the influence of the Mm musculus Myo D1 allele on the efficiency of skeletal muscle regeneration. J Anat 190:223-227 (1997).

Iacopetta BJ, Harmon D, Spagnolo DV, House AK, Kay PH. Hypermethylation of the Myf-3 gene in human colorectal cancer. Anticancer Res 17:429-432 (1997).

Harmon D, Kay PH. Polymorphism of Pax7 in the wild mouse gene pool. Mouse Genome 94:868-870 (1996).

Hähnel R, Harvey J, Kay PH. Hypermethylation of the myogenic gene Myf-3 in human breast carcinomas. Anticancer Res 16:2111-2116 (1996).

Marlow SA, Kay PH, Papadimitriou JM. Polymorphism of the mouse E2A gene due to an intronic deletion of 536 bp. Gene 168:143-149 (1996).

Kay PH, Jacobsen PF, Taylor J, Spagnolo DV. The significance of DNA methylation in cancer. Adv Anat Path 2:353-361 (1995).

Lynch DM, Kay PH. Studies on the polymorphism of the fifth component of complement in laboratory mice. Exp Clin Immunogenet 12:253-260 (1995)

Kay PH, Mitchell CA, Akkari A, Papadimitriou JM. Association of an unusual form of a Pax7-like gene with increased efficiency of skeletal muscle regeneration. Gene 163:171-177 (1995).

Kay PH, Taylor J, Kees UR, Baker DL, Spagnolo DV. Myf-3 hypermethylation in malignant lymphoproliferative disorders. Int J Cancer 62:797-799 (1995).

Marlow SA, Kay PH, Papadimitriou JM. Myo-D1 alleles distinguish between Mm domesticus and Mm musculus subspecies. Mouse Genome 93:436-438 (1995).

Marlow SA, Kay PH, Papadimitriou JM. Polymorphism of the murine inhibitor of differentiation-controlling gene Id. Gene 153:281-282 (1995).

Ashman RB, Kay PH, Lynch DM, Ott K. Association of a complement allotype (C3F) with acute inflammatory responses to Candida albicans infection. Med J Aust 160:732-733 (1994).

Spagnolo DV, Taylor J, Carrello S, Saueracker E, Kay PH. Southern blot analysis of lymphoproliferative disorders : use and limitations in routine surgical pathology. Pathology 26:268-275 (1994).

Kay PH, Pereira E, Marlow SA, Turbett G, Mitchell CA, Jacobsen PF, Holliday R, Papadimitriou JM. Evidence for adenine methylation within the mouse myogenic gene Myo-D1. Gene 151:89-95 (1994).

Marlow SA, Kay PH, Papadimitriou JM. Polymorphism of the mouse transcription factor-encoding gene E2A. Gene 141:303-304 (1994)

Kay PH, Marlow SA, Mitchell CA, Papadimitriou JM. Studies on the evolution and function of different forms of the mouse myogenic gene Myo-D1 and upstream flanking region. Gene 124:215-222 (1993).

Lynch DM, Ashman, RB, Kay PH, Papadimitriou JM. Genetic structural and functional studies of a complement C3-like protein in the marsupial Setonix brachyurus. Exp Clin Immunogenet 10:195-201 (1993).

Lynch DM, Kay PH, Papadimitriou, JM, Grounds MD. Studies on the structure of complement C3 and the stability of C3 derived phagocytic ligands C3b/iC3b in SJL/J and BALB/c mice. Eur J Immunogenet 20:1-9 (1993).

Pavlovic M, Kay PH, Moriuchi J, Jacobsen PF, Papadimitriou JM. TaqI polymorphism of the epidermal growth factor receptor gene in Caucasoids and Japanese. Human Heredity 43:39-44 (1993).

Kay PH, Moriuchi J, Ma PJ and Saueracker E. An unusual allelic form of the immunoglobulin lambda constant region genes in the Japanese. Immunogenetics 35:341-343 (1992).

Saueracker EA, Kay PH, Spagnolo DV. Distinguishing between monoclonal rearrangements and allelic forms of the immunoglobulin lambda light chain constant region genes. Diagn Mol Path 1:109-117 (1992).

Ashman RB, Kay PH, Lynch D, Papadimitriou JM. Murine candidiasis. Sex differences in the severity of tissue lesions are not associated with levels of serum C3 and C5. Immunol Cell Biol 69:7-10 (1991).

Kay PH, Jacobsen PF, Zheng M-H, Papadimitriou JM. Genetic polymorphism of the murine myogenic gene Myo-D1. Gene 99:273-277 (1991).

Kay PH, Marlow S, George A. Heterogeneity of the wild mouse (house mouse) Myo-D1 gene pool in Western Australia. Proc Australian Physiol Pharmacol Soc 22:181-186(1991).

Uko GP, Dawkins RL, Mohammed I, Kay PH, Christiansen FT, Nasidi A, Bajani M. Bf S gene frequency in Nigerians with HIV infection. Disease Markers 9:333-338 (1991).

Dawkins RL, Martin E, Saueracker G, Kay PH, Leaver A, Christiansen FT. Supratypes and ancestral haplotypes in IDDM: potential importance of central non-HLA MHC genes. J Autoimmunity 1:63-68 (1990).

Kay PH, Papadimitriou JM. What's new in the role of complement in disease? Path Res & Pract 186:410-414 (1990).

Dawkins RL, Leaver A, Cameron PU, Martin E, Kay PH, Christiansen FT. Some disease associated ancestral haplotypes carry a polymorphism of TNF. Hum Immunol 26:91-97

Tokunaga K, Kay PH, Christiansen FT, Saueracker G, Dawkins RL. Comparative mapping of the human major histocompatibility complex in different racial groups by pulsed field gel electrophoresis. Hum Immunol 26:99-106 (1989).

Cameron PU, Cobain TJ, Zhang WJ, Kay PH, Dawkins RL. Influence of C4 null genes on infection with human immunodeficiency virus. Br Med J Clin Res 296; 1627-1628(1988).

Kay PH, Dawkins RL, Williamson J, Tokunaga K, Christiansen FT, Charoenwong P. Coexistence of an MHC chromosomal segment marked by HLA B17, BfS, C4A6, B1, DR7, and DQw9 in different ethnic groups. Hum Immunol 23:27-35 (1988).

Kay PH, Martin E, Dawkins RL, Charoenwong P. Class III gene rearrangements in Thai/Chinese supratypes containing null or defective C4 alleles. Immunogenetics 27:46-50 (1988).

Tokunaga K, Saueracker G, Kay PH, Christiansen FT, Anand R, Dawkins RL. Extensive deletions and insertions in different MHC supratypes detected by pulsed field gel electrophoresis. J Exp Med 168:933-940 (1988).

Warlow RS, Uko G, Feeney DJ, Kay PH. HLA, C4, Bf, Gm and autoantibodies in rheumatoid arthritis. Exp Clin Immunogenet 5:133-142 (1988).

Zhang WJ, Kay PH, Cobain TJ, Dawkins RL. C4 allotyping on plasma or serum: application to routine laboratories. Hum Immunol 21:165-171 (1988).

Dawkins RL, Kay PH, Garlepp MJ, Christiansen FT. Immunogenetics of spontaneous, drug-induced, and experimental myasthenia gravis. Ann NY Acad Sci 505:398-406(1987).

Dawkins RL, Martin E, Kay PH, Garlepp MJ, Wilton AN, Stuckey MS. Heterogeneity of steroid 21-hydroxylase genes in classical congenital adrenal hyperplasia. J. Immunogenet 14:89-98 (1987).

Kay PH, Dawkins RL, Bowling AT, Bernoco D. Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes. J. Immunogenet 14:247-253 (1987).

Kay PH, Dawkins RL, Bowling AT, Bernoco D. Polymorphism of the acetylcholine receptor in the horse. Veterinary Record 120:363-365 (1987).

Kay PH, Grimsley G, Dawkins RL, Charoenwong P. MHC supratypes as markers of null and defective C4 alleles in a Thai/Chinese population: relevance to disease susceptibility. Disease Markers 5:43-47 (1987).

Musk AW, Zilko PJ, Manners P, Kay PH, Kamboh MI. Genetic studies in familial fibrosing alveolitis. Possible linkage with immunoglobulin allotypes (Gm). Chest 89:206-210 (1986).

Warlow RS, Uko G, McCluskey J, Kay PH, Christiansen FT, Dawkins RL. Extractable nuclear antigen (ENA) autoantibodies in SLE: an immunogenetic relationship with HLA, C4 and Bf alleles. Clin Exp Immunol 63:419-427 (1986).

Day MJ, Kay PH, Clark WT, Shaw SE, Penhale WJ, Dawkins RL. Complement C4 allotype association with and serum C4 concentration in an autoimmune disease in the dog. Clin Immunol Immunopathol 35:85-91 (1985).

Kay PH, Dawkins RL, Christiansen FT. Sex influences transmission of the supratype, associated with the C2 deficiency allele: a possible mechanism for the maintenance of heterozygosity and disease susceptibility. Hum Immunol 12:185-189 (1985).

Kay PH, Dawkins RL, Penhale JW. The molecular structure of different polymorphic forms of canine C3 and C4. Immunogenetics 21:313-319 (1985).

Kay PH, Natsuume-Sakai S, Hayakawa J, Dawkins RL. Different allotypes of C3, degrade at different rates. Immunogenetics 22:563-569 (1985).

Kay PH, Wilton AN, Dawkins RL. Preferential paternal transmission of the diabetogenic supratype marked by HLA B18 BfF1 DR3. Journal of Immunogenetics 12:327-329(1985).

Kelly H, McCann VJ, Kay PH, Dawkins RL. TI Susceptibility to IDDM is marked by MHC supratypes rather than individual alleles. Immunogenetics 22:643-651 (1985).

Uko G, Dawkins RL, Kay PH, Christiansen FT, Hollingsworth PN, CR1 deficiency in SLE: acquired or genetic?. Clin Exp.Immunol 62:329-336 (1985).

Warlow RS, Garlepp M, Feeney D, Kay PH, Swanson N, Dawkins RL. Antiacetylcholine receptor and antinuclear antibodies in myasthenia gravis. Correlation with HLA, sex and Gm. Exp Clin Immunogenet 2:158-163 (1985).

Warlow RS, Kay PH, McCluskey J, Uko G, Dawkins RL. Secondary Sjogren's syndrome and chromosome six markers. Tissue Antigens 25:247-254 (1985).

Garlepp MJ, Kay PH, Farrow BR, Dawkins RL. Autoimmunity in spontaneous myasthenia gravis in dogs. Clin Immunol Immunopathol 31:301-306 (1984).

Kay PH, Dawkins RL. Genetic polymorphism of complement C4 in the dog. Tissue Antigens 23:151-155 (1984).

McCann VJ, McCluskey J, Kelly H, Kay PH, Zilko PJ, Christiansen FT, Dawkins RL. Thyrogastric autoimmunity and MHC associated alleles at the C4 locus in patients with type 1 (insulin-dependent) diabetes. Diabetologia 27:124-125 (1984).

Beilby JP, Dick M, Kay PH, Watson FE. The microheterogeneities of thyroxine-binding globulin and alpha 1 protease inhibitor (alpha 1-antitrypsin) are interrelated. Clinica Chimica Acta 133:51-63, (1983).

Christiansen FT, Dawkins RL, Uko G, McCluskey J, Kay PH, Zilko PJ. Complement allotyping in SLE: association with C4A null. Aust NZ J Med 13:483-488 (1983).

Dawkins RL, Christiansen FT, Kay PH, Garlepp M, McCluskey J, Hollingsworth PN, Zilko PJ. Disease associations with complotypes, supratypes and haplotypes. Immunol Rev 70:1-22 (1983).

Dawkins RL, Kay PH, Christiansen FT. Immunogenetics of rheumatoid arthritis. Ann Acad Med, Singapore 12:155-163 (1983).

Dawkins RL, Uko G, Christiansen FT, Kay PH. Low C4 concentrations in insulin dependent diabetes mellitus. [letter]. Br Med J Clin Res 287:839 (1983).

Kay PH, McCluskey J, Christiansen FT, Feeney D, McCann VJ, Zilko PJ, Dawkins RL, O'Neill GJ. Complement allotyping reveals new genetic markers in rheumatoid arthritis and diabetes mellitus. Tissue Antigens 21:159-160 (1983).

McCann VJ, McCluskey J, Kay PH, Zilko PJ, Christiansen FT, Dawkins RL. HLA and complement genetic markers in diabetic retinopathy [letter]. Diabetologia 24:221 (1983).

McCluskey J, , McCann VJ, Kay PH, Zilko PJ, Christiansen FT, O'Neill GJ, Dawkins RL. HLA and complement allotypes in Type 1 (insulin-dependent) diabetes. Diabetologia 24:162-165 (1983).

McCluskey J, Kay PH, Stuckey M, Christiansen FT, Dawkins RL, Wilson G. MHC "supratype" predicting heterozygous 21-hydroxylase deficiency [letter]. Lancet 1:764-765(1983).

Uko G, Christiansen FT, Dawkins RL, Kay PH. Low serum C4 concentrations in insulin dependent diabetes mellitus. [letter]. Br Med J Clin Res 286:1748-1749, (1983).

Garlepp MJ, Kay PH, Dawkins RL. The diagnostic significance of autoantibodies to the acetylcholine receptor. J Neuroimmunol 3:337-350 (1982).

O'Neill GJ, Nerl CW, Kay PH, Christiansen FT, McCluskey J, Dawkins RL. Complement C4 is a marker for adult rheumatoid arthritis [letter]. Lancet 2:214 (1982).

Garlepp MJ, Kay PH, Dawkins RL, Bucknall RC, Kemp A. Cross-reactivity of anti-acetylcholine receptor autoantibodies. Muscle & Nerve 4:282-288 (1981).