Science Catch-up. Blame Your Genes If You Don’t Lose Weight?

by The Health Sciences Academy — Get free science updates here.

Welcome to our Thursday’s Science Catch-up: curated links by The Health Sciences Academy. Get our email updates every other Thursday here (it’s free).

Let’s catch you up with studies and news that recently made the headlines!

Click on your favourite topics to read our summary:

1. Blame your genes if you don’t lose weight?

2. Excessive antioxidants may interfere with your stress response

3. Garlic breath? Try this fix!

4. Can you avoid cadmium and lead in chocolate?

5. Too much gluten could trigger coeliac disease in babies

6. Feeding babies allergens reduces food allergies

7. Fermented soymilk isoflavones lower your UV damage?

8. Why people struggle with new dietary foods (and what helps)

Blame your genes if you don’t lose weight?

Study link


If you inherited the FTO gene mutations, you’re 70% more likely to be obese.

But does this mean you can blame your genes for failing to lose weight?

Not exactly!

This meta-analysis involving 9,563 participants shows that carrying these FTO mutations didn’t stop them from losing weight.

That’s good news. You’re not doomed by your obesity genes when trying to lose excess weight.

Getting smarter with your food and being more physically active will help – regardless of what you inherited in the genetic lottery!

Note: Indeed, the foods we eat can influence the expression of our genes! If you wish to learn more about this, see our Science Report From Food to DNA: Can Gene Expression Be Changed? (optional resource).

Excessive antioxidants may interfere with your stress response

Study link

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Normal ROS signals promote beneficial antioxidant adaptations in cells (Blackwell et al., 2016)

This new study from Harvard colleagues cautions that we shouldn’t “overdose” on antioxidant supplements.

When you exercise, for example, your body produces more oxygen free radicals, called ROS (reactive oxygen species), which are very unstable molecules that can damage your DNA.

Excess ROS is often portrayed as harmful, and it has been linked to accelerated ageing, inflammation, and even increased cancer risk.

However, it appears that a little bit of these unstable oxygen free radicals in your cells is beneficial. This is because they stimulate your natural antioxidant response, increasing your cells’ resistance to stress and promoting favourable metabolic adaptations.

In other words, they nudge your natural antioxidant defence to get better.

The problem highlighted in this study is that antioxidants can be too efficient at eliminating these ROS molecules. And this may interfere with those normal ROS signals that are helpful and important for detoxification and anti-ageing effects.

These findings remind us that too much of a good thing can also be bad… and that benefits are often dose-dependent. In this case, from antioxidant supplements.

Note: When taken correctly, antioxidant supplements can be very advantageous. But when consumed in the wrong doses or combinations, they can do more harm than good. You can learn how to safely adjust doses for different individuals in our Advanced Dietary Supplements Advisor course.

Garlic breath? Try this fix!

Study link

The sulphide compounds in garlic are potent activators of genes responsible for detoxification (via the process of epigenetics).

But these same compounds also produce the scent that no one likes (gasp!) which sticks around on your breath… sometimes over 24 hours.

So what to do?

If you’re a garlic lover but those around you can’t stand your garlic breath, scientists may have found a partial solution to your halitosis. And it’s actually quite simple!

Eating a raw apple or a bunch of raw lettuce may help reduce your garlic breath by 50%.

The study participants had to chew raw garlic cloves for 25 seconds. After that, they had raw apple or lettuce, which decreased the concentration of sulphide volatiles by 50% in 30 minutes.

Mint leaves had a higher level of deodorization, and green tea had no deodorising effect whatsoever.

So now you know! Here’s the comparative data (notice raw apple and raw lettuce on top):

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Effects of different foods and drinks on the deodorisation of garlic breath (Mirondo and Barringer, 2016)

Can you avoid cadmium and lead in chocolate?

News link

This might come as a shock to you: Chocolate, whether raw or not, has carcinogenic heavy metals like cadmium and lead.

And no, this unsuspected addition has nothing to do with food manufacturers!

These trace metals come from the soil in which the cocoa tree grows. And it appears that the concentrations are a bit higher in organic cocoa.

So how do we avoid these harmful heavy metals?

We can’t. But it’s just tiny traces, and some governments have specific rules for producers.

For example, in California (US) you’ll see a warning label if the product has more than 4.1mcg per daily serving.

In Europe, the EFSA set new maximum levels of cadmium effective from 2019:

  • 10 mg/kg in milk chocolate
  • 30 mg/kg in chocolate with 30% to 50% cocoa
  • 80 mg/kg in chocolate with over 50% cocoa
  • 60 mg/kg in cocoa powder

To reduce cadmium accumulation in the soil, producers can elevate the pH by applying lime or micronutrients like zinc.

Young children are at a higher risk, particularly if they have too much chocolate.

This is because their detoxification systems aren’t yet fully developed. Besides, their bodies are smaller so the concentration in tissue can be higher.

The tolerable weekly intake limit for cadmium is 2.5 mcg per kilogram of body weight.

But the EU says that European consumers could be exceeding this limit:


Consumers are likely to be exceeding their daily cadmium intake limit (Scientific Panel on Contaminants in the Food Chain)

Too much gluten could trigger coeliac disease in babies

News link


Infants eating more than 5 grams of gluten per day were more than twice as likely to become coeliac (Aronsson et al., 2016)

If you carry one of the HLA gene variants DR3-DQ2 or DR4-DQ8, it means that you’re more susceptible to developing coeliac disease from eating gluten. However, it doesn’t mean you’ll get it for sure.

This study is an example of that.

High gluten intake before the age of 2 increased the infants’ coeliac disease risk if they carried these HLA variants. But lower intakes didn’t.

So it’s not about avoiding gluten completely. It’s about the amount babies are fed.

The infants eating more than 5 grams of gluten per day were more than twice as likely to become coeliac than those who ate less.

The findings also debunked the myth that introducing gluten too early (before 17 weeks) or too late (after 26 weeks) is linked with the development of the disease.

In other words, it’s the excessive amount of gluten that triggers coeliac in babies with the genetic risk, rather than the timing of its introduction.

Note: Gluten is a protein which is naturally found in grains such as wheat, rye, and barley. Gluten-free alternatives include millet, corn (maize), quinoa, and rice. You can learn more about managing coeliac disease in our Food Allergies and Intolerances course.

Feeding babies allergens reduces food allergies

News link

Before new moms panic after the coeliac news above, a little bit of food-allergen exposure seems to do some good.

Researchers stipulate that introducing allergenic foods like peanuts, fish, wheat, or eggs at an early age may reduce the risk of developing a food allergy.


Examples of lower risk of food allergy from earlier introduction (Boyle et al., 2016)

Fermented soymilk isoflavones lower your UV damage?

News link

According to this Japanese study, consuming fermented soymilk products, such as soymilk yogurt, may help protect against UV radiation damage by increasing the number of isoflavones in the body. Isoflavones are phytochemical compounds with multiple beneficial effects. But UV protection is an unexpected one!

Why people struggle with new dietary foods (and what helps)

Study link


One of the studies analysed tested several kiwi textures (Giacalone and Jaeger, 2016)

It seems that product familiarity is one of the main reasons we struggle to include new foods into our existing diets.

This systematic review highlighted the difficulty to embrace novel flavours, different textures, new brands, or reformulated products with less fat or less sugar.

This should be a reminder of how important eating psychology is when trying to make smarter food choices. You can’t just ignore it.

It takes a massive cognitive effort to evaluate unfamiliar foods, reason why working with a nutrition professional (our grads!) makes it a lot easier.

If you want to get the latest science and our tips, make sure you sign up to our Thursday emails HERE.

What’s your key learning from today’s Science Catch-up? What do you think of some of these discoveries? Tell us in the comments below!

The-Health-Sciences-Academy-Alejandra-Ruani-small1-right Alex Ruani, Doctoral Researcher, is the Chief Science Educator at The Health Sciences Academy, where her team of accomplished scientists and PhDs are training a new breed of over 100,000 highly-specialised nutrition professionals who are leveraging the latest personalisation strategies to help their clients. She is a Harvard-trained scientist and UCL Doctoral Researcher who is fanatical about equipping health professionals with the latest science-based tools so they can succeed in their practices – from identifying the unique nutrient needs to building highly personalised nutrition programs. Besides investigating and teaching the latest advances in health and nutrition biochemistry, Alex makes it easier to be smarter with her free email updates.

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